医局員紹介
教授 中村 典史 Norifumi NAKAMURA mail
生 年 |
1957 年 | ||
就任年月 |
2005年 10月 現職 2013年 4月 鹿児島大学病院副病院長 2014年 4月 鹿児島大学病院長補佐(-2017年3月) 2013年 4月 インドネシア大学歯学部 Visiting Professor 2013年 9月 エアランガ大学歯学部 Visiting Professor 2014年 8月 インドネシア大学歯学部 Adjunctive Professor 2021年 4月 ブラウィジャヤ大学歯学部Visiting Professor |
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最終学歴 |
九州大学歯学部 | ||
学 位 |
博士(歯学)・九州大学 | ||
所属学会 |
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International Association of Oral and Maxillofacial Surgery American Cleft Palate Craniofacial Association Asian Association of Oral and Maxillofacial Surgery (Reviewer) 口腔顔面神経機能学会:理事長(口唇・舌感覚異常判定認定医第14号) 日本口腔外科学会:評議員、日本口腔外科学会専門医第360号、指導医第583号、専門医制度委員会委員、国際委員会委員 日本口腔科学会:評議員、認定医、指導医(1-16054号) 日本口蓋裂裂学会: 理事、 評議員、編集委員会委員長、学術調査委員会委員、診療ガイドライン作成委員会委員、優秀論文賞選考委員会委員、優秀ポスター賞選考委員会委員、JapanCleft 委員会委員、口蓋裂認定治療師(口腔外科3 号)、学術委員会委員、学術研究委員会委員 日本小児口腔外科学会:理事、評議員、論文査読・学術用語委員会委員、表彰選考・選挙管理委員会委員 日本口腔腫瘍学会:評議員 日本インプラント学会:代議員 日本口腔内科学会:専門医(第25号), 指導医(第47号) 日本顎顔面神経機能学会: 副理事長(口唇・舌感覚異常判定認定医第14号) 日本有病者歯科医学会:評議員 日本顎変形症学会:代議員 日本音声言語医学会 |
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専門分野 |
口腔顎顔面外科学 | ||
研究テーマ |
○口唇口蓋裂の包括的医療に関する研究 ○手術後瘢痕拘縮の分子メカニズムの解明 ○口蓋裂言語障害の可視化並びに病態の解明 ○顎骨嚢胞の病態と治療に関する臨床的、基礎的研究 ○エナメル上皮腫の増殖・分化に関する基礎的研究 | ||
キーワード |
口唇口蓋裂、先天異常、歯原性腫瘍、エナメル上皮腫、顎骨嚢胞 | ||
研究業績 |
【著書・総説】 ●中村典史(分担執筆) アルコール依存症、薬物依存症の口腔内所見 歯科医のための内科学, 医歯薬出版, 2021/03, pp 272-274. ●中村典史: 7章 歯原性腫瘍, 共著, 口腔外科学 第4版, 医歯薬出版, 2020;237-258. ●中村典史: 14章 歯・歯槽および歯周組織の外科, 共著, 口腔外科学 第4版, 医歯薬出版, 2020;507-519. ●中村典史: 貧血, 共著, 歯科衛生士必須有病者歯科学, 永末書店, 2020;93-94. ●Fuchigami T, Ono Y, Kishida S, Nakamura N: Molecular Biological findings of ameloblastoma. Japanese Dental Science Review 57(Suppl.1):27-32, 2021,査読あり. ●中村典史, 渕上貴央, 岐部俊郎, 石畑清秀: 歯原性腫瘍・嚢胞研究からみえる歯原性上皮の防御機構. 歯界展望 2020;136:1181-1194. 査読なし. ●Nakamura N, Fuchigami T, Kibe T, Ishihata K, Mitsuyasu T, HiguchiY: Surgical approach for ameloblastoma considering its growth characteristics. Ameloblastoma, Chapter 19, Ed. Benny S Latif, Faculty of Dental Medicine, University of Indonesia, Jakarta, pp506-518, 2019. ●中村典史分担執筆): 口唇裂. 坂下英明, 編著 子どもの口と顎の異常・病変, クインテッセンス出版, 東京, 33-41, 2019. ●中村典史, 野添悦郎: 色々な感覚異常の種類とその診断. 口腔外科ハンドマニュアル’19, クインテッセンス出版, 東京, 124-129, 2019. ●瀬尾憲司, 福田謙一, 佐久間泰司, 今村佳樹, 坂本英治, 佐々木研一, 照光 真, 中村典史, 山口重樹, 吉本裕代: 歯科治療による下歯槽神経・舌神経損傷の診断とその治療に関するガイドライン 治療編, 日本歯科麻酔学会, 日本口腔顔面痛学会, 日本口腔外科学会, 日本ペインクリニック学会, 口腔顔面神経機能学会編 445, 61-71, 2019. ●中村典史, 石畑清秀, 小松澤均: 歯根?胞- 生体バリアの最前線としての?胞裏装上皮を考える. 歯界展望, 医歯薬出版, 東京, 133巻第1号, 47-56, 2019. ●中村典史: 貧血、今井 裕,岩淵博史 編著,有病者歯科学. 永末書店,京都,2018,pp 93-94. ●石畑清秀,中村典史:歯性感染病巣における上皮形成の意義. 月刊「細胞」, 2018;50:485-489. ●中村典史(分担執筆): 第3章16.顎顔面に症状が見られる症候群と系統的骨疾患, 榎本昭二,編著 最新口腔外科学 第5版, 医歯薬出版,東京,2017,pp452-467. ●中村典史,野添悦郎,大河内孝子: 下顎智歯2回法抜歯術の術式と10年間の臨床成績. 歯界展望130(6):1051-1066, 2017. ●Nakamura N, Tezuka M:Surgical strategy of cleft palate repair and nasometric results. in Designing Strategies for Cleft Lip and Palate Care, Chapter 4.InTech Open Acess Publisher, 2017, pp61-72. ●中村典史(分担執筆):栢 豪洋、升井一朗、他編集、歯科衛生士のためのポケット版 最新・歯科用語辞典, クインテッセンス出版, 東京, 2016. ●中村典史、手塚征宏(分担執筆): 呼吸障害, 夏目長門 編集、言語聴覚士のための基礎知識 臨床歯科医学・口腔外科学第2版、医学書院、東京、2016, pp224-225. ●中村典史(分担執筆): 口腔外科手術の基本的手術 3)?胞の手術1)経?胞開窓摘出術, 角 保徳、樋口勝規、梅村長生、柴原孝彦、編著、 臨床口腔外科学、第2編 一からわかる診断から手術. 医歯薬出版、東京、2016. pp.278-281. ●中村典史、石畑清秀、柚木寿理:小児口腔外科手術の周術期管理.日口外誌 62(9):432-440, 2016. ●中村典史(分担執筆):野間弘康、瀬戸皖一、監修、 先天異常および発育異常、顔面・口腔の発生と先天異常、口唇裂口蓋裂の治療.標準口腔外科学第4版、医学書院、東京、2015, pp111-114, pp131-136. ●Nozoe E, et al.: Simple method for evaluation of facial asymmetry using a frontal facial photograph. Oral Science in Japan 2014. Japanese Stomatological Society, Tokyo, 2015, pp.43-46. ● 野添悦郎、中村典史:下顎智歯2回法抜歯の実際.口腔外科ハンドマニュアル’14. 日本口腔外科学会編.”10年先を見据えて口腔外科医療のパラダイムシフト”特集3:埋伏智歯の抜歯を考えるー求められる知識とテクニックー. クインテッセンス出版, 東京, 2014.86-95. ● 田松裕一、中村典史:サイエンス:軟口蓋を校正する筋群の形態・機能と口蓋裂の治療.日本歯科医学会雑誌 67(4):19-27, 2014. ● 中村典史、他:患者家族への心理的サポートを知ってほしい口唇裂・口蓋裂の現状.ザ・クインテッセンス33 (8):152-159, 2014. ● Suzuki H, et al.: Cancer cachexia - pathology and management-. J Gastroenterol 48:574-594 2013. ● Suzuki H, et al.: Cancer cachexia pathophysiology and translational aspect of herbal medicine. Jpn J Clin Oncol 43:695-705, 2013. ● Ogata Y, et al.: A trial for characterizing the behaviors of velopharyngeal closure insufficiency under various oral pressure conditions in cleft palate, In Cleft Lip and Palate: Etiology, Surgery & Repair and Sociopsychological Consequences. Eds Noemi Jaso and Ana Maria D’Cruz, Nova Science Publishers Inc. New York, 145-158, 2013. ● Suzuki H, et al.: Ghrelin and cachexia in chronic kidney disease. Pediatr Nephrol 28:521-526, 2013. ● Suzuki H, et al.: Cachexia and herbal medicine: Perspective. Current Pharmaceutical Design 18: 4865-4888, 2012. ● Nakamura N: Surgical strategy for secondary correction of unilateral and bilateral cleft lip-nose deformities. Chapter 5, In Rhinoplasty. InTech Open Access Publisher, Croatia, 2011, pp 57-70. ● Kawada-Matsuo M, et al. : Role of two-component systems in the resistance of Staphylococcus aureus to antibacterial agents. Virulence 2(5):427-430, 2011. ● 中村典史(分担執筆):日本口腔外科学会、編著、口腔顎顔面外科学専門用語集. 医歯薬出版、東京、2011.pp 144-152. ● 中村典史:NAM・口唇外鼻一体移動による低侵襲初回口唇外鼻形成の取り組み.日口外誌,56(11):618-627,2010. ● 中村典史(分担執筆):一からわかる口腔外科疾患の診断と治療 角 保徳、樋口勝規、他編著、増補版、第3編 疾患の概要・治療、Part 1 口腔外科:治療方針、嚢胞pp299-309、先天異常、後天異常 pp324-334、Part 2 口腔外科小手術の基本手技、嚢胞・腫瘍の手術pp364-366, こんな偶発症にどう対応するか、上顎洞穿孔pp387--389、医歯薬出版、2010. ● 中村典史:変治唇裂の二次修正手術.小児口外誌, 19(2):1-7,2010. ● 中村典史:特集:鹿児島大学歯学部の地域貢献: アジア発展途上国における口唇口蓋裂医療援助を振り返って 鹿児島大学歯学部紀要, 30: 15-19, 2010. ●中村典史(分担執筆):口腔外科学 第3版、白砂兼光、古郷幹彦編著、第14章、歯・歯槽および周辺組織の外科、pp 505-516,医歯薬出版、2010. ● 中村典史、他:口腔外科 YEAR BOOK/一般臨床家、口腔外科医のためのハンドマニュアル'07 特集3 唇顎口蓋裂症例の長期経過観察、両側性完全唇顎口蓋裂の一貫治療クインテッセンス出版、2007, pp128-129. ● 中村典史:今日の治療指針2007年版-私はこう治療している、舌痛症.医学書院、2007, pp1090-1091. ● 中村典史:今日の治療指針2006年版-私はこう治療している、第26章歯科・口腔疾患、口腔ケア、医学書院、2006, pp1095-1096. ● Surgical Pathology; Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics. In KL Zakariasen, et al. (Eds.), The 2003 Year Book of Dentistry, Mosby, 2003, pp 179-180. ● Nakamura N, et al.: Postoperative resorption of transplanted bone along tooth roots adjacent to the alveolar cleft. Dentistry in Japan 38:73-76, 2002. ●中村典史(分担執筆):言語聴覚法シリーズ8巻、器質的構音障害、斉藤裕恵編著、第1章II 発声発語器官の解剖と生理 pp 4-12、第2章 I 口唇口蓋裂の基礎知識 pp 8-27、IV 手術 pp 55-62、第3章I 言語臨床の方針と内容 pp 113-115、建帛社、2002. ● Nakamura N, et al.: Surgical management of alveolar cleft in cleft lip and palate patients considering development of teeth and alveolar bone, pp 42-50. Kombinansi Perawatan Bedah Dan Ortodonti Pada Pencangkokan Tulang Sekunder Kasus Celah Gusi (Indonesian), pp 99-120, Buku Seminar Penanganan Komprehensif Kasus Celah Bibir dan langit-langit, In Program SEHATI (Ed.) Jakarta, 1996. 【原著】 ●Kibe T, Ishihata K, Takako T, Fuchigami T, Takahashi T, Kamakura S, Suzuki O, Iino-Maeda A, Miyawaki S, Nakamura N: A follow-up study on the clinical outcomes of alveolar reconstruction using octacalcium phosphate and atelocollagen complex. J Oral and Maxillofacial Surgery, E-published ahead of print, 2021. ●Shinagawa N, Minami K, Ishida T, HijiokaH, Yamamoto M, Kawahara K, Shinsato Y, Furukawa T, Nakamura N: Combination of hydroxyurea and tranilast suppress gemcitabine- resistance induced by ribonucleotide reductase M1 in gemcitabine- resistant cells. Oral Science International, 2021;18:169-177. ●Seong CH, Chiba N, Kusuyama J, Amir SM, Nakamura N, Matsuguchi T: Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts. FEBS Letters 559(3):389-403,2021. ●Hiromoto S, Nozoe E, Hanada K, Yoshimura T, Shima K, Kibe T, Nakamura N: In vivo degradation and bone formation behaviors of hydroxyapatite-coated Mg alloys in rat femur. Mater Sci Eng C 122(9):111942, 2021. ●Mardiyantoro F, Prasetyangrum N, CahyatiM, Abidin ZZ, Nakamura N: Potential effect of djambal catfish (pangasis djambal) gelatin as biomaterial product on healing socket after tooth extraction in rats. Indian Journal of Forensic Medicine & Toxicology 15(2):2379-2387, 2021. ●Tajitsu M, Ishihata K, Tezuka M, Yoshimura T, Ichiki M, Ohta H, Nohara K, Nakamura N: Effectiveness of fiberoptic endoscopic evaluation of swallowing and dietary intervention during home-visit dental care in older individuals. Gerodontology, 2021;00:1-5. ●Kamadjaja DB, Abidin, ZZ, Diana R, Kharis I, Sumarta NPM, Amir SM, Rizqiawan A, Danudiningrat CP, Nakamura N: In vivo analyses of osteogenic activities and bone regeneration capacity of demineralized freeze-dried bovine bone xenograft: A potential candidate for alveolar bone fillers. International Journal of Dentistry, 2021, Article ID 1724374, 10 pages ●Yoshimura T, Suzuki H, Takayama H, Higashi S, Hirano Y, Tezuka M, Ishida T, Ishihata K, Amitani M, Amitani H, Nishi Y, Nakamura Y, Imamura Y, Nozoe E, Nakamura N: Prognostic role of preoperative sarcopenia evaluation of cervical muscles with long-term outcomes of patients with oral squamous cell carcinoma. Cancers (Basel) 13(18):4725, 2021. ●Tezuka M, Kamikuri Y, Ishihata K, Kibe T, Fuchigami T, Amir SM, Matsunaga K, Nakamura N: Comparison of recurrence rate and speech outcome between two different techniques for cleft palatal fistula closure: A retrospective cohort study. J Cranio-Maxillofac Surg, E-published ahead of print, 2021. ●吉村卓也、鈴木 甫、高山大生、東 翔太郎、平野憂花、手塚征宏、石田喬之、中村康典、野添悦郎、中村典史:口腔扁平上皮癌患者の予後に対する術前低予後栄養指数および高筋肉内脂肪含有量の影響(二次投稿)日口外誌 67(6): 410-416, 2021. ●鈴木 甫、吉村卓也、手塚征宏、田中孝明、福永 香、網谷真理恵、網谷東方、中村典史:「種子島スタディ」―口腔から種子島地域高齢者の健康寿命延伸につなげる包括的高齢者機能評価―地域ケアリング23(7):43-46, 2021. ●香西早苗、中新美保子、稲川喜一、井上信次、手塚征宏4、岐部俊郎、中村典史:口唇裂・口蓋裂児のQOLにおける自己評価と保護者による評価の検討.日口蓋誌 46(3): 153-159, 2021. ●鈴木 甫,吉村卓也,手塚征宏,田中孝明,福永 香,網谷真理恵,網谷東方,水間喜美子,改元 香,渡邉里美, 東 翔太朗,高山大生,榎本 孝,日高直人,山中寿和,下川昭代,中村康典,油田幸子,今村也寸志,中村典史:『種子島スタディ』?口腔から種子島地域高齢者の健康寿命延伸につなげる包括的高齢者機能評価?Teethful (鹿児島県歯科医師会誌) 2021154(733):7-9. ●Yamashita K, Kibe T, Shidou R, Kohjitani A, Nakamura N, Sugimura M: Difference in the effects of lidocaine with epinephrine and prilocaine with felypressin on the autonomic nervous system during extraction of the impacted mandibular third molar: A randomized controlled trial. J Oral Maxillofac Surg 2020;78:215.e1-215.e8. 査読有り. ●Fuchigami T, Suzuki H, Yoshimura T, Kibe T, Chairani E, Kishida M, Kishida S, Nakamura N: Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model. Journal of Applied Oral Science 2020;28:e20190558. 査読有り. ●Kawai T, Kamakura S, Matsui K, Fukuda M, Takano H, Iino M, Ishikawa S, Kawana H, Soma T, Imamura E, Kizu H, Michibata A, Asahina I, Miura K, Nakamura N, Kibe T, Suzuki O, Takahashi T: Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery. Journal of Tissue Engineering 2020;11:1-15. 査読有り. ●Al-Tayar BA, Ahmad, Yusoff AME, Abdullah SF, Mohamad NH, Hashim SNM, Kishida S, Kishida M, Nakamura N, Kibe T, Harun MH: Cytotoxic effects of Betel quid and areca nut aqueous extracts on mouse fibroblast, human mouth-ordinary-epithelium 1 and human oral squamous cell carcinoma cell lines. Asian Pac J Cancer Prev 2020;21:1005-1009. 査読有り. ●Koga T, Kibe T, Taguchi T, Fuchigami T, Nishihara K, Ishihata K, Nakamura N: Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film. Oral Science Int18(1):40-49, 2020. 査読有り. ●Okawachi T, Ishihata K, Kimura N, Fuchigami T, Nozoe E, Nakamura N: Using three-dimensional nasal forms to compare definitive unilateral cleft lip nose correction with/without a cross-lap joint cartilage graft technique. J Cranio-Maxillofac Surg 2020;48:1035-1044. 査読有り. ●Yoshimura T, Suzuki H, Takayama H, Higashi S, Hirano Y, Tezuka M, Ishida T, Ishihata K, Nishi Y, Nakamura Y, Imamura Y, Nozoe E, Nakamura N: Impact of preoperative malnutrition and abnormal body composition such as high intramuscular adipose tissue content on outcomes of patients with oral squamous cell carcinoma. Cancers 2020;12:3167. 査読有り. ●Kume K, Hijioka H, Ishida T, Okawachi T, Nishihara K, Sugiura T, Nakamura N: A case of esthetic reconstruction for full-thickness cheek, oral commissure, and vermilion defects following extensive resection of advanced buccal carcinoma. J Oral Maxillofacial Surgery, Medicine and Pathology 2020;32:261-266. 査読有り. ●Tezuka M, Hirahara N, Kamikuri Y, Ishida T, Nakamura N: Alternative successful functional recovery of total full-thickness velar defect following recurrent oropharyngeal carcinoma resection: A case report. J Oral Maxillofacial Surgery, Medicine and Pathology 2020;32:498-502. 査読有り. ●中囿賢太, 石畑清秀, 岐部俊郎, 手塚征宏, 渕上貴央, 中村典史: 口唇形成術後に肺炎加療を要した13トリソミーの1例. 日口蓋誌 2020;45(3):220-224. 査読有り. ●春山直人, 鈴木 陽, 野口健志, 野村俊介, 吉崎恵悟, 落合 聡, 笹栗正明, 光安岳志, 森山雅文, 中村典史, 高橋一郎: 両側性口唇顎裂ならびに上顎両側重視部に複数の副顎を伴う両側性横眼裂Tessier 分類7型)患者の臨床的特徴・出生から14歳までの経過観察. 日本頭蓋顎顔面外科学会誌, 2020; 37(1):印刷中. 査読有り. ●Fuchigami T, et al.: Comparison of short-term effects of pre-surgical nasoalveolar molding and Hotz’s plate on the maxillary arch from in unilateral cleft lip and palate. J Oral Maxillofac Surg Med Pathol, 31(1):25-30, 2019. ●Suzuki H, et al.: Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. Sci Rep. 12;9(1):6011, 2019. ●Amir MS, et al.: Reliabilities of Americleft Yardstick nasolabial appearance assessment with/without basal view for Japanese children with unilateral complete cleft lip and palate. Cleft Palate-Craniofacial J, 56(7):953-959, 2019. ●Kimura N, et al.: Pilot study of visual and quantitative image analysis of facial surface asymmetry in unilateral complete cleft lip and palate. Cleft Palate-Craniofacial J, 56 (7):960-969, 2019. ●Dwi A, et al.: Correlation of Basic Fibroblast Growth Factor expression in palatal mucoperiosteal tissue with maxillary growth in operated cleft palate patients. J International Dental and Medical Research, 12(1): 61-70, 2019. ●Yamashita K, et al.: Time of recovery of feeding after alveolar bone graft surgery in associated with postoperative nausea and vomiting within 2 hours in school-age children. Clin Med Insights Pediatr. 13:1179556519855387, 2019. ●Ripon S, et al.: Effect of cigarette smoke extract on mitochondrial heme-metabolism: An in vitro model of oral cancer progression. Toxicol In Vitro. 60:336-346, 2019. ●Matsunaga K, et al.: Swallowing function before and after subtotal glossectomy and reconstruction with a rectus abdominis musculocutaneous flap. Surgical Science, 10(8): 271-280, 2019. ●Ishihata K, et al.: Assessment of postoperative complications using E-PASS and APACHE II in patients undergoing oral and maxillofacial surgery. Patient Safty in Surgery, 2018;5:12:3. ●Honjyo K, et al.: CP4/PEP19 upreglates aromatase gene expression via CYP19A1 Promoter 1.1.in human breast cancer SK-BR-3 cells. Oncotarget. 2018 Jul 3;9(51):29619-29633. ●Kimura N, et al.: Three-dimensional analyses of nasolabial forms and upper lip surface symmetry after primary lip repair in patients with complete unilateral cleft lip and palate. J Cranio-maxillofacial Surgery, 2018; 47(2) 245-252. ●渕上貴央,岐部俊郎,木村奈美子,手塚征宏,ムハマッド スバン アミール、松永和秀、中村典史:顎裂部自家腸骨海綿骨移植術における再骨部の術後創部状態はRoher Indexと相関する. 日口蓋誌 43(1): 6-11, 2018. ●田中荘子、中村康典、西 恭宏、下松孝太、中村典史: 鹿児島医療センターにおける心臓弁膜症手術患者の周術期口腔機能管理の現状. 日本口腔ケア学会誌13(1): 21-27, 2018. ●Honjo K, Yamada S, Hiraki T, Higashi M, Noguchi H, Yoshimura T, Yokoyama S, Batra SK, Yonezawa S, Semba I, Nakamura N, Tanimoto A: Immunohistochemical expression profile of Mucin antigens in salivary gland mucoepidermoid carcinoma ? MUC4- and MUC6-negatice expression predicts shortened survival in the early postoperative phase. Histol Histopathol 33(2):201-213, 2018. ●Fuchigami T, Kimura N, Kibe T, Tezuka M, Subhan MA, Suga H, Takemoto Y, Hashiguchi M, Maeda-Iino A, Nakamura N: Effects of pre-surgical nasoalveolar moulding on maxillary arch and nasal form in unilateral cleft lip and palate before lip surgery. Orthodontics and Craniofacial Research 20(4):209-215, 2017. ●Fuchigami T, Koyama H, Kishida M, Nishizawa Y, Iijima M, Kibe T, Ueda M, Kiyono T, Maniwa Y, Nakamura N, Kishida S: Fibroblasts promote the collective invasion of ameloblastoma tumor cells in a 3D coculture model. FEBS Open Bio, 7(12):2000-2007, 2017. ●Maeda-Iino A, Marutani K, Furukawa M, Nakagawa S, Kwon S, Kibe T, Tezuka M, Nakamura N, Miyawaki S: Evaluation of upper central incisors on the non-cleft and cleft sides in patients with unilateral cleft lip and palate ? Part 1: Relationship between root length and orthodontic tooth movement. Angle Orthodontist 87(6):855-862, 2017. ●Maeda-Iino A, Furukawa M, Kwon S, Marutani K, Nakagawa S, Fuchigami T, Nakamura N, Miyawaki S: Evaluation of upper central incisors on the non-cleft and cleft sides in patients with unilateral cleft lip and palate ? Part 2: Relationship of root resorption with horizontal tooth movement and quantity of grafted autogenous bone. 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Molecular and Clinical Oncology 3(1):55-62, 2105. ● Fuchigami T, et al.: Regulation of IL-6 and IL-8 production by reciprocal cell-to-cell interaction between ameloblastoma and stromal fibroblasts through IL-1α. Biochemical and Biophysical Research Communications (BBRC) 451: 491-496, 2014. ● Tezuka M, et al.: Perceptual and videofluoloscopic analyses on relationship between backed articulation and velopharyngeal closure following cleft palate repair. Oral Science International: 11(2): 60-67, 2014. ● Nishihara K, et al.: Outcome following secondary autogenous bone grafting before and after canine eruption in patients with unilateral cleft lip and palate. Cleft Palate-Craniofac J: 51(2): 165-171, 2014. ● Maeda A, et al.: Changes in grafted autogenous bone during Edgewise treatment in patients with unilateral cleft lip/palate or alveolus. Cleft Palate-Craniofac J: 51(6):525-532,2014. ● Fuchigami T, et al.: Short-term molding effects on the upper alveolar arch following unilateral cleft lip repair with/without nasal vestibular expansion. Cleft Palate-Craniofac J:51(6):557-568,2014. ● Sasaguri M, et al.: Effects of Hotz’s plate and lip adhesion on maxillary arch in patients with complete unilateral cleft lip and palate until 5 Years of age. J Oral Surg Med Path 26(3):292-300, 2014. ● Nishihara K, et al.: Outcome following secondary autogenous bone grafting before and after canine eruption in patients with unilateral cleft lip and palate. Cleft Palate-Craniofac J: 51(2): 165-171, 2014. ● Sulaiman FK, et al.: 15-year follow-up results after presurgical orthopedics followed by primary correction for unilateral cleft lip nose in Program SEHAT, Indonesia. Cleft Palate-Craniofac J: 50(2): 129-137, 2013. ● Kawada-Matsuo M, et al.: Three distinct two-component systems are involved in the resistance to class I bacteriocins, nisin A, and nukacin ISK-1 in Staphylococcus aureus. PLoS ONE, 8(7): e69455, 2013. ● Nakao Y, et al.: Fibroblast growth factor-7 and -10 stimulate cell proliferation in ameloblastoma via mitogen-activated protein kinase pathway". Int J Oncology, 43: 1377-1384, 2013. ● Ishida T, et al.:Notch signal induces EMT in oral squamous cell carcinoma under hypoxic environment. Oncology Letters, 6(5): 1201-1206, 2013. ● Ishihata K, et al.:Newly developed endotoxin measurement method (Endotoxin Activity Assay) may reflect the severity of sepsis. Open J Pathology 3: 1-6, 2013. ● Kume K, et al.: The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein-2. Biochemical and Biophysical Research Communications (BBRC) 430(3): 889-894, 2013. ● Ishihata K,et al.: Expression of anti-microbial peptides and E-cadherin in periapical lesions. Oral Science International 10(2):70-76, 2013. ● Matsumoto K,et al.: Surgical strategy for primary bilateral cleft lip and palate and short-term outcomes in comparison to those of healthy children. Oral Science International 10(2):77-86, 2013. ● Kibe T, et al.: A novel ameloblastoma cell line (AM3) secretes MMP-9 in response to Wnt-3a and induces osteoclastgenesis. Oral Surg Oral Med Oral Pathol Oral Radiol & Endod 115(6): 780-788, 2013. ● Shimomatsu K, et al.:T hree dimensional analyses of facial soft configuration of Japanese females with jaw deformity ?A trial for polygonal exhibition of the soft tissue forms in patients with orthognathic surgery-.Int J Oral and Maxillofac Surg: 40(7): 559-567, 2012. ● Yoshimine S, et al.: Topographic analysis of maxillary premolars and molars and maxillary sinus using cone beam computed tomography.Implant Dentistry 21(6):528-535, 2012. ● Miyawaki A, et al.:Analysis of the outcome of concurrent neoadjuvant cheoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma. Oncology Letter, 3:995-1001, 2012. ● Nakamura N, et al.: Three dimensional analyses of nasal forms after secondary treatment of bilateral cleft lip-nose deformity in comparison to those of young adults.J Oral Maxillofac Surg 69:e469-e481, 2011. ● Matsunaga K, et al.: Association between preoperative inferior rectus muscles swelling and outcomes in orbital blowout fracture. J Cranio-Maxillofacial Surg 39(7):509-514, 2011. ● Kibe T, et al.: Immortalization and characterization of MOE1 cells, normal oral epithelial cell lines without using HPV and SV40 genes-. Oral Science International 8: 20-28, 2011. ● Yoshida Y, et al.: Bacitracin resistants TCSs and transporters in Staphylococcus aureus. FEMS Microbiol Lett 320(1):33-39, 2011. ● Nakamura N, et al.: Secondary correction of bilateral cleft lip nose deformity ?clinical and three-dimensional observations on pre- and postoperative outcomes-. J Cranio-Maxillo-Facial Surg 39(5):305-312, 2011. ● Okawachi T, et al.: Three dimensional analyses of nasal forms following secondary correction of unilateral cleft lip nose deformity.J Oral Maxillofac Surg 69(2):322-332, 2011. ● Kawada-Matsuo M, et al.: Role of two-component systems in the resistance of Staphylococcus aureus to antibacterial agents. Virulence 2(5):427-430, 2011. ● Miyawaki A, et al.: Relationship between SUV of PET and hypoxic environment of oral squamous cell carcinoma. Oncology Report 23: 1205-1212, 2010. ● Hijioka H, et al.: Up-regulation of Notch pathway molecule in oral squamous cell carcinoma. Int J Oncology 36: 817-822, 2010. ● Nakamura N, et al.: Surgical technique for secondary correction of unilateral cleft lip-nose deformity: Clinical and 3-dimensional observations of preoperative and postoperative nasal forms, J Oral Maxillofac Surg 68 (9): 2248-2257, 2010. ● Tanaka C, et al.: Comparison of the anorexigenic activity of CRF family peptides. Biochemical and Biophysical Research Communications (BBRC) 390(3): 887-891, 2009. ●Nakamura N, et al.: Postoperative nasal forms after presurgical nasoalveolar molding followed by medial-upward advancement of nasolabial components with vestibular expansion of children with unilateral cleft lip and palate, J Oral Maxillofac Surg 67(10): 2222-2231, 2009. ●Ogata Y, et al.: Effects of Bulb-PLP therapy on nasality and velopharyngeal function of patient following palatoplasty. Oral Science International 6(2): 73-84, 2009. ● Lee C, et al.: A follow up Study of autogenous bone graft combining Platelet-Rich Plasma in alveolar cleft - Quantitative radiological assessment of density and resorption of grafted bone. Int J Oral Maxillofac Surg 39:118-125, 2009. ● Nishikubo M, et al.: 3-D analysis of palatal morphology associated with palatalized articulation in patients with unilateral cleft lip and palate. Oral Science Int. 6(1): 36-45, 2009. ● Hendarmin L, et al.: An anti-apoptotic role of NF-kB in TNFα-induced apoptosis in ameloblastoma cell line. Oral Science International 5(2): 96-103, 2008 ● Nakayama E, et al.: New development of an interventional sialoendoscopy for real non-surgical sialolithectomy using intracorporeal electrohydraulic lithotripsy. J Oral Maxillofac Surg 65: 1402-1405, 2007. ● Ishida T, et al.: Effect of Acetaminophen, a cyclooxygenase inhibitor on Morris water maze task performance in mice. J Psychopharmacology 21 (7): 757-767, 2007. ● Suzuki A, et al.: Retrospective evaluation of treatment outcome in Japanese children with complete unilateral cleft lip and palate. Part 1: 5 Year olds' index for dental arch relationships. Cleft Palate-Craniofac J 44: 434-443, 2007. ● Sandra F, et al.: Inhibition of Akt and MAPK pathways elevated potential of TNF alpha inducing apoptosis in ameloblastoma. Oral Oncol 42: 39-45, 2006. ● Nakamura N, et al.: An alternative method for vermilion reconstruction after resection of hemangioma of the lip. J Oral Maxillofac Surg 63(8): 1239-1243, 2005. ● Fujita S, et al.: Retrospective evaluation of dentofacial growth of the isolated cleft palate children: from cheiloplasty to adolescence. Cleft Palate-Craniofac J 42(6): 625-632, 2005 ● Nakamura N, et al.: A longitudinal study on influence of primary facial deformities on maxillofacial growth in patients with cleft lip and palate. Cleft Palate-Craniofac J 42(6): 633-640, 2005 ● Hendarmin L, et al.: TNFα played a role in induction of Akt and MAPK signals in ameloblastoma. Oral Oncology 41: 375-382, 2005. ● Sandra F, et al: Ameloblastoma induces osteoclastogenesis: A possible role of ameloblastoma in expanding in the bone. Oral Oncology 41:637-644, 2005 ● Sandra F, et al: TRAIL cleaves caspase-8, -9 and -3 of AM-1 cells; A possible pathway for TRAIL to induce apoptosis in ameloblastoma. Tumor Biol 26: 258-264, 2005. ● Kawano S, et al.: Characterization of dental epithelial progenitor cells derived from cervical-loop epithelium in a rat lower incisor. J Dental Research 83(2):129-133, 2004. ● Nakamura N, et al.: Endoscopic removal of a dental implant displaced into the maxillary sinus: Techinical report. Int J Oral Maxillofac Sur 33(2):195-197, 2004. ● Sandra F, et al.: Midkine induced growth of ameloblastoma through MAPK and Akt Pathways. Oral Oncology 40(3): 274-280, 2004. ● Nakamura N, et al.: Aerodynamic and cephalometric analyses of velopharyngeal structure and function following re-pushback surgery for secondary correction in cleft palate. Cleft Palate- Craniofac J 40(1): 46-53, 2003. ● Nakamura N, et al.: Velopharyngeal morphology of patients with persistent velopharyngeal incompetence following repushback surgery for cleft palate. Cleft Palate-Craniofac J 40(6): 612-617, 2003. ● Nakamura N, et al.: Comparison of long-term results between different approaches to amelobalstoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(1):13-20, 2002. ● Nakamura N, et al.: Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94(5):543-553, 2002. ● Honda Y, wet al.: Relationship between primary palatal form and maxillofacial growth in Japanese children with unilateral cleft lip and palate: infancy to adolescence. Cleft Palate- Craniofac J 39(5):527-534, 2002. ● Kawano S, et al. Establishment of dental epithelial cell line (HAT-7) and the cell differentiation dependent on Notch signaling pathway. Connective Tissue Research 43(3):409-412, 2002. ● Sandra F, et al.: The role of MDM2 in the proliferative activity of ameloblastoma. Oral Oncology 38:153-157, 2002. ● Nakamura N, et al.: Growth charactristics of ameloblastomas involving the inferior alveolar nerve - A clinical and histopathologic study-. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91(5):557-562, 2001. ● Sandra F, et al.: Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma. Oral Oncology 37:193-198, 2001. ● Sandra F, et al.: Two relatively distinct pattern of ameloblastoma: an anti-apoptotic proliferation site in the outer layer (periphery) and a pro-apoptotic differentiating site in the inner layer (center). Histopathology 39:93-98, 2001. ● Harada H, et al.: Establishment of ameloblastoma cell line, AM-1. J Oral Pathol Med 27(5): 207-212, 1998. ● Mitsuyasu T, et al.: Immunohistological demonstration of bcl-2 in ameloblastoma. J Oral Pathol & Med 26 (8): 345-348, 1997. ● Suzuki A, et al.: Cephalometric comparison of craniofacial morphology between primary bone grafted and nongrafted complete unilateral cleft lip and palate adults. Cleft Palate-Craniofac J 33(5): 429-435, 1996. ● Nakamura N, et al.: Marsupialization of cystic ameloblastoma: A clinical and histopathologic study of the growth characteristics before and after marsupialization. J Oral Maxillofac Surg 53 (7): 748-754, 1995. | ||
講演会 |
●Norifumi Nakamura: Dentist’s Job in CLP patients. Presurgical and postsurgical treatment for patients with CLP, Dentofacial growth and development-Update in Dentistry, The 3 in One Program at Faculty of Dentistry Universitas Brawijaya, 2020/09/21-24. Malang-Indonesia, 招待有り. ●Norifumi Nakamura: Dental management using bone graft in the alveolar cleft and orthognathic surgery. The 3 in One Program at Faculty of Dentistry Universitas Brawijaya, 2020/09/21-24. Malang-Indonesia, 招待有り. ●Norifumi Nakamura: Comprehensive management of cleft lip and palate: The Role of Dentists, DACOTA Program; Video Conference with Airlangga University, 2020/09/26, Surabaya-Indonesia, 招待有り. ●Norifumi Nakamura: Introduction-Kagoshima University, Faculty of Dentistry. 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/21, Malang-Indonesia. ●Norifumi Nakamura: Introduction of CLP treatment and dentofacial development, 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/22, Malang-Indonesia. ●Norifumi Nakamura: Cleft lip and palate; Global view of cleft lip and palate and presurgical treatment of CLP, 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/22, Malang-Indonesia. ●Norifumi Nakamura: Labioplasty & Secondary correction of lip and nose. 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/23, Malang-Indonesia. ●Norifumi Nakamura: Palatoplasty and speech management of CP and Prosthetic speech appliance. 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/23, Malang-Indonesia. ●Norifumi Nakamura: Management of malocclusion Orthognathic surgery for CLP patients. 3 in one Visiting Lecture Program Universitas Brawijaya, 2020/09/24, Malang-Indonesia. ●中村典史: 歯原性腫瘍・嚢胞研究からみえてくる次世代型歯科治療のあり方. 九州お茶の水会学術セミナー, 2020/01/11, 福岡市. |
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研究内容 |
研究活動は、主としてエナメル上皮腫を中心とする歯原性腫瘍の増殖と分化メカニズムの解明と、口唇口蓋裂の包括的治療に関する研究を行っている。 歯原性腫瘍に関する研究では、同疾患の治療成績を向上させるために、臨床的ならびに病理組織学的、免疫組織化学的見地よりその病態や生物学的特性を明らかにし、診断や外科的治療などの臨床面にフィードバックすることを行ってきた。なかでも、準悪性腫瘍とされる、エナメル上皮腫については、腫瘍の増殖メカニズムの解明のために発育浸潤様式の組織形態学的検索、増殖および分化に関する分子生物学的特性を検索している。また、これらの研究結果をもとに、エナメル上皮腫の保存的治療を実践し、顎顔面形態ならびに機能を温存しながら、顎骨切除療法と同等の治療成績を収めてきた。さらに、歯根嚢胞についても、嚢胞上皮の発生・増殖に関わる分子メカニズムの解明を通して、歯原性嚢胞上皮の感染防禦機序における役割について研究している。 口唇口蓋裂については、チーム医療体制の整備によって医療の質の向上を図ると共に、口唇外鼻形成術後の三次元的形態評価,顎顔面発育障害や言語障害などの病態の解明とその対策について研究を行ってきた。また、顎裂部への二次的骨移植術により、本疾患患者の機能的ならびに解剖学的な口腔機能の回復を図ると共に。移植骨の吸収などの合併症に関わる因子を追求し、治療成績の向上を図った。近年では、口蓋裂術後の瘢痕形成の分子メカニズムの解明、ならびに、創面新規被覆材の開発などの研究に従事している。 |
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授業科目 |
口腔顎顔面外科学、顎顔面形成外科学、顎顔面形成外科学演習、顎顔面形成外科学実験(院) | ||
受賞歴 |
●優秀演題発表賞, 第78回日本矯正歯科学会学術大会, 2019年11月20-22日, 長崎 ●Poster presentation 1st prize, 13th World Conference of ICPF, Nagoya, July 27, 2019. ●優秀論文賞, 43回日本口蓋裂学会総会・学術総会, 2019年5月31日, 新潟 ●優秀ポスター賞, 第43回日本口蓋裂学会総会・学術総会, 2019年5月31日, 新潟 ●平成16年 4月 第58回日本口腔科学会賞 ●平成16年 10月 第 6回アジア口腔顎顔面外科学会賞 ●平成16年 11月 第43回大韓顎顔面形成再建外科学会学術賞 ●平成17年 10月 第50回日本口腔外科学会ゴールドリボン賞 ●平成19年 10月 89th Annual Meeting of American Association of Oral and Maxillofacial Surgeons,Best International Basic Science Research Poster Presentation Award ●平成24年 5月 平成23年度口腔科学会学術奨励賞 ●平成25年 5月 第37回日本口蓋裂学会優秀ポスター賞 ●平成25年 10月 第46回MBC賞(鹿児島大学病院口唇口蓋裂専門外来として) ●平成26年 5月 平成25年度日本口腔科学会学術奨励賞 |
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資格等 |
●日本口腔内科学会専門医(第47号), 日本口腔内科学会指導医(第25号) ●歯科医師臨床研修指導歯科医 ●中村典史: 一般財団法人日本口蓋裂学会口唇裂・口蓋裂認定師(口腔外科分野) |
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社会連携活動 |
●The Microsurgery Course in Oral and Maxillofacial Approach, July 20, 21, 2019 in Jakarta, Indonesia. ●鹿児島大学病院CLP専門外来公開講座「口唇口蓋裂児を支える看護職のための研修- 鹿児島県の一貫治療と専門職連携 ?」, 2019年12月8日, 鹿児島 ●アイルランガ大学歯学部付属病院口唇口蓋裂ボランティア手術活動および技術移転, 2019年11月20日, スラバヤ市, インドネシア 国内における社会連携活動としては、鹿児島大学病院にて、口唇口蓋裂専門外来の活動の一環として口唇裂口蓋裂児出生前、出生直後の産科医院への往診システムを立ち上げ、口唇口蓋裂児の口蓋床による超早期栄養管理、患者家族への心理的サポートに努めている。また,2006年、鹿児島口唇口蓋裂親の会「もみじ会」を再設立し、顧問として運営に携わり、年2回の講演会活動,屋外活動,交流会などを企画運営している. 国外においては、1995年より2年間、インドネシア共和国のハラパンキタ小児産科病院口唇口蓋裂センターに駐在し、現地医師、歯科医師らに口唇口蓋裂チーム医療に関する知識や技術の伝達を図ってきた。その際、低栄養により死亡する口蓋裂児が多い同国の状況に対して、出生直後からの口蓋床導入によって哺乳状況を改善し、また、顎誘導処置によって外科治療成績の向上に取り組んだ。1997年,帰国後は同病院のsupervisorとして技術指導,啓蒙活動を継続している.1998年以降は、インドネシア、バングラデシュ、エチオピアなどの発展途上国に短期出張し、口唇口蓋裂患者の外科的治療を中心に現地スタッフの指導を行うと共に、同疾患患者の抱える諸問題に対するチーム医療の重要性について啓蒙活動を行っている。また,2011年以降,日本口唇口蓋裂協会等のサポートのもとエチオピアにおける口唇口蓋裂海外医療活動を展開し、上述の社会活動が評価されて、第46回MBC賞(南日本放送社賞、鹿児島大学病院口唇口蓋裂専門外来代表として)を受賞した. |