Prof. MAJIMA's Home page



鹿児島大学大学院医歯学総合研究科腫瘍学講座顎顔面放射線学研究分野・宇宙環境医学講座 教授 馬嶋秀行


  (学術のページ)            宇宙放射線学とミトコンドリア 

 
日本ミトコンドリア学会のHPへ    



<経歴>

●昭和58年3月  日本大学大学院歯学研究科修了(放射線基礎医学専攻
●昭和54年4月  放射線医学総合研究所臨床研究部研究生
〜昭和58年3月
●昭和56年7月  ハーバード大学医学部マサチューセッツ総合病院
〜昭和57年7月  放射線腫瘍治療科研究員(日本大学海外留学生派遣制度による)
●昭和58年4月  東京大学医学部助手(放射線基礎医学講座)
〜平成 元年7月
●昭和62年8月  ハーバード大学医学部マサチューセッツ総合病院 放射線腫瘍治療科研究員
〜平成 元年7月
●平成 9年7月  放射線医学総合研究所 主任研究員 宇宙放射線防護プロジェクト
〜平成13年7月
●平成12年4月  文部科学省 研究振興局 ライフサイエンス課専門官(併任) 
〜平成13年3月
●平成13年4月  文部科学省 宇宙開発委員会安全部会特別委員

●平成13年8月  鹿児島大学歯学部歯科放射線学講座 教授
●平成15年4月  鹿児島大学大学院医歯学総合研究科腫瘍学講座顎顔面放射線学専攻・宇宙環境医学講座 教授

●平成22年4月  国際宇宙ステーション“きぼう”Neuro Rad 実験実施
●平成23年5月  国際宇宙ステーション“きぼう”宇宙焼酎プロジェクト実施
●平成24年7月  文部科学省 科学技術・学術審議会専門委員
     

●現在に至る

●他、宇宙滞在皮膚プロジェクト、宇宙飛行士“HAIR”Project、ネムリユスリカ宇宙プロジェクト実施中



<最近の研究テーマ>

■放射線・酸化ストレスとミトコンドリア
■MnSOD と生体防御
■宇宙線の細胞に対する影響
■酸化ストレスによる遺伝子発現
■老化とミトコンドリア



<主な研究業績>


◆Suenaga S, Nagayama K, Nagasawa T, Indo HP, Majima HJ. The usefulnes of diagonostic imaging for the assessment of pain symptoms in temporomandibular disorders.JDSR 42(4) 93-106 2016.
◆Maeda, K, Kawai H, Sanada M, Terashima T, Ogawa N, Idehara, R, Makiishi T, Yasuda H, Sato S, Hoshi K, Yahikozawa H, Nishi K, Itoh Y, Ogasawara K, Tomita T, Indo HP, Majima HJ: Similar clinical phenotype and segregation of mitochondrial 3243A>G mutation in two pairs of monozygotic twins. JAMA Neurology, 2016 in press.
◆Yonenaga K, Majima HJ, Oyama S, Ishibashi K, Tanno H: Diagnosis and evaluation of 100 dysphagia patients using videoendoscopy at a core hospital of a local city in Japan. Odontology, 2016 in press.
◆Ito M, Matsui H, Hirayama A, Indo HP, Majima HJ, Hyodo I: Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells, J Clin Biochem Nutr, Vol.58, No.3, 180-185 2016.
Majima HJ, Indo HP, Nakanishi I, Suenaga S, Matsumoto K, Matsui H, Minamiyama Y, Ichikawa H, Yen H-C, Hawkins CL, Davies MJ, Ozawa T, St Clair DK: Chasing Great Paths of Helmut Sies “Oxidative Stress”. Arch Biochem Biophys, Vol.595, 54-60 2016.
◆Suenaga S, Nagayama K, Nagasawa T, Kawabata Y, Indo H, Majima HJ: Evaluation of the relationship between contrast-enhanced magnetic resonance characteristics and joint pain in patients with temporomandibular disorders,Oral Radiol, Vol.32, No.2, 87-97 2016.
◆川畑義裕、長澤大成、守山泰司、野添悦郎、河野一典、末永重明、犬童寛子、中村典史、仙波伊知郎、馬嶋秀行: MRIにて『おはじき』(Marble)様の典型所見を呈した類比嚢胞、歯科放射線、55巻2号 (印刷中)
◆Terada M, Seki M, Takahashi R, Yamada S, Higashibata A, Majima HJ, Sudoh M, Mukai C, Ishioka N: Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station. PLos ONE, Vol.11, No.3, e0150801 2016.
◆Indo HP, Matsui H, Chen J, Zhu H, Hawkins CL, Davies MJ, Yarana C, St Clair DK, Majima HJ: Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion. J Clin Biochem Nutr, Vol.57, No.1, 13-20 2015.
◆Indo HP, Tomiyoshi T, Suenaga S, Tomita K, Suzuki H, Masuda D, Terada M, Ishioka N, Gusev O, Cornette R, Okuda T, Mukai C, Majima HJ: MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. Journal of Clinical Biochemistry and Nutrition Vol.57, No.2, 98-104 2015.
◆Indo HP, Yen H-C, Nakanishi I, Matsumoto K, Tamura M, Nagano Y, Matsui H, Gusev RO, Cornette R, Okuda T, Minamiyama Y, Ichikawa H, Suenaga S, Oki M, Sato T, Ozawa T, St, Clair DK,Majima HJ: A Mitochondrial Superoxide Theory for Oxidative Stress Diseases and Aging., J Clin Biochem Nurt, Vol.56, No.1, 1-7 2015.
◆Ito H, Matsui H, Tamura M, Majima HJ, Indo HP, Hyodo I: Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect., J Clin Biochem Nutr , Vol.55, No.1, 67-71 2014.
◆Ito H, Tamura M, Matsui H, Majima HJ, Indo HP, Hyodo I: Reactive oxygen species involved cancer cellular specific 5-aminolevulinic acid uptake in gastric epithelial cells. , J Clin Biochem Nutr. , Vol.54, No.2, 81-85 2014.
◆Tamura M, Matsui H, Tomita T, Sadakata H, Indo HP, Majima HJ, Kaneko T, Hyodo I: Mitochondrial reactive oxygen species accelerate gastric cancer cell invasion. , J Clin Biochem Nutr., Vol.54, No.1, 12-17 2014.
◆Terada T, Seki M, Higashibata A, Higashibata A, Yamada S, Takahashi R, Majima HJ, Yamazaki T, WatanabeAsaka T, Niihori M, Mukai C, Ishioka N: Genetic analysis of the human hair roots as a tool for spaceflight experiments., Adv Biosci Biotechnol, Vol.4, No.10B, 75-88 2013.
◆Nakanishi-Ueda T, Majima HJ, Watanabe K, Ueda T, Indo HP, Suenaga S, Hisamitsu T, Ozawa T, Yasuhara H, Koide R: Blue LED light exposure develops intracellular reactive oxygen species, lipid peroxidation, and subsequent cellular injuries in cultured bovine retinal pigment epithelial cells. , Free Radic Res , Vol.47, No.10, 774-780 2013.
◆Tamura M, Matsui H, Nagano YN, Kaneko T, Indo HP, Majima HJ, Hyodo I: Salt is an oxidative stressor for gastric epithelial cells., J Physiol Pharmacol, Vol.64, No.1, 89-94 2013.
◆Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ , Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M: Snail modulates cell metabolism in MDCK cells. BBRC Vol.432, No.4, pp.618-625 2013 in press
◆Indo HP, Nakanishi I, Ohkubo K, Yen H-C, Nyui M, Manda S, Matsumoto K, Fukuhara K, Anzai K, Ikota N, Matsui H, MinamiyamaY, Nakajima A, Ichikawa H, Fukuzumi S, Ozawa T, Mukai C and Majima HJ: Comparison of in vivo and in vitro antioxidative parameters for eleven food factors. RSC advances, Vol.3, No.14, 4535-4538 2013
◆Yano S, Masuda D, Kasahara H, Katsunori Omori K, Higashibata A, Asashima M, Ohnishi T, Yatagai F, Kamisaka S, Furusawa T, Higashitani A, Majima HJ, Nikawa T, Wakabayashi K, Takahashi H, Suzuki H, Shimazu T, Fukui K, Hattori A, Tanigaki F, Shirakawa M, Nakamura T, Yoshimura Y, Suzuki N, Ishioka N: Excellent Thermal Control Ability of Cell Biology Experiment Facility (CBEF) for Ground-Based Experiments and Experiments Onboard the Kibo Japanese Experiment Module of International Space Station. Biological Sciences in Space.26 : 12-20 2012.
◆Indo HP, Inanami O, Koumura T, Suenaga S, Yen H-C, Kakinuma S, Matsumoto K, Nakanishi I, St Clair W, St Clair DK, Matsui H, Cornette R, Gusev O, Okuda T, Nakagawa Y, Ozawa T & Majima HJ: Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radical Research, Vol. 46, No. 8: 1029-1043 2012.
◆Nagano Y, Matsui H, Shimokawa O, Hirayama A, Tamura M, Nakamura Y, Kaneko T, Rai K, Indo HP, Majima HJ, Hyodo I. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells. J Physiol Pharmacol. 63(2) 137-142. April 2012.
◆Terada M, Kawano F, Ishioka N, Higashibata A, Majima HJ, Yamazaki T, Watanabe-Asaka T, Nihori M, Nakao R, Yamada S, Mukai C, Ohira Y: Biomedical Analysis of Rat Body Hair after Hindlimb Suspension for 14 days. Acta Astronautica 73, 23-29, 2012.: October 27, 2011.
◆Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo HP, Majima HJ, Hyodo I: Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells. J Gastroenterol. 46(10):1167-1176, 2011.
Majima, HJ, Indo, HP, Suenaga, S, Matsui, H, Yen, H-C and Ozawa, T: Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative Stress-Related Diseases. Curr Pharm Des 17(21) 2190-2195, 2011.
◆Yen H-C, Li SH, Majima HJ, Huang YH, Chen CP, Liu CC, Tu YC, Chen CW: Upregulation of antioxidant enzymes and coenzyme Q10 in a human oral cancer cell line with acquired bleomycin resistance. Free Radical Research Jun;45(6):707-716, 2011. Epub 2011 Apr 12.
◆Sato T, Morita Y, Kawabata Y, Majima H, Sugihara K: Making the best use of our previous results as a clue for interpreting kinetics of scintigraphic agents. Japanese Dental Science Review 47(2), 131-140, 2011.
◆Rai K, Matsui H, Kaneko T, Nagano Y, Shimokawa O, Udo J, Hirayama A, Hyodo I, Indo HP, Majima HJ: Lansoprazole inhibits mitochondrial superoxide production and cellular lipid peroxidation induced by indomethacin in RGM1 cells. J Clin Biochem Nutr. Jul;49(1):25-30, 2011.
Majima HJ, Indo HP, Suenaga S, Kaneko T, Matsui H, Yen H-C, Ozawa T: Mitochondria as Source of Free Radicals. Naito Y, Suematsu M, Yoshikawa T (eds): Free Radical Biology in Digestive Diseases, Front Gastrointest Res. Basel, Karger, vol 29, pp12-22, 2011.
◆Nagayama K, Suenaga S, Nagata J, Takada H, Majima HJ, Miyawaki S: Clinical significance of magnetization transfer contrast imaging for edematous changes in masticatory muscle. J Comput Assist Tomogr, 34(2): 233-241, 2010.
Majima HJ, Indo HP, Tomita K, Iwashita Y, Suzuki H, Masuda D, Shimazu T, Tanigaki F, Umemura S, Yano S, Fukui K, Higashibata A, Yamazaki TQ, Kameyama M, Suenaga S, Sato T, Yen H-C, Gusev O, Okuda T, Matsui H, Ozawa T, Ishioka N: Bio-assessment of risk in long-term manned space exploration ? cell death factors in space radiation and/or microgravity: a review -. Biol Sci Space 23(2): 43-53, 2009.
◆Lee C, Nishihara K, Okawachi T, Iwashita Y, Majima HJ, Nakamura N: A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft, Int J Oral Maxillofac Surg. 38(2):117-125, 2009.
◆Shimokawa O, Matsui H, Nagano Y, Kaneko T, Shibahara T, Nakahara A, Hyodo I, Yanaka A, Majima HJ, Nakamura Y and Matsuzaki Y: Neoplastic transformation and induction of H+,K+-adenosine triphosphatase by N-methyl-N'-nitro-Nnitrosoguanidine in the gastric epithelial RGM-1 cell line.  In Vitro Cell. & Develop. Biol., Animal, 44(1-2):26-30, 2008.
◆Nong Q, Komatsu M, Izumo K, Indo HP, Xu B, Aoyama K, Majima HJ, Horiuchi M, Morimoto K and Takeuchi T: Involvement of reactive oxygen species in MCLR-induced cytogenotoxicity. Free Rad. Res.41(12):1326-1337, 2007.
◆Indo HP, Davidson M, Yen H-C, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 7(1-2):106-118, 2007.
◆Indo H, Suenaga S, Nozoe E, Nakamura N, Tanuma J, Semba I, Majima HJ: Pleomorphic adenoma presenting low T2 signal-intensity on magnetic resonance imaging. Dentomaxillofac Radiol, 35(5):380-382, 2006.
◆Ohira Y, Kawano F, Wang X.D, Sudoh M, Iwashita Y, Majima HJ, Nonaka I: Irreversible morphological changes in leg bone following chronic gravitational unloading of growing rats. Life Sci. 2006 Mar 6; [Epub ahead of print].
◆Sato T, Kawabata Y, Saigo Y, Iwashita Y, Suenaga S, Indo H, Hamahira S, Kawano K, Nitta T, Morita Y, Majima H, Sugihara K: Interpretation of scintigraphic findings of oral malignant tumours with a new scanning agent of technetium-99m-hexakis- 2-methoxy-isobutyl-isonitrile (Tc-99m-MIBI). Dentomaxillofac Radiol. 35(1):24-29, 2006
◆Sato T, Kawabata Y, Nitta T, Saigo Y, Iwashita Y, Suenaga S, Hamahira S, Indo H, Morita Y, Majima HJ, Sugihara K: Expression of permeability-glycoprotein (P-gp) and uptake of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (99Tcm-MIBI) in malignant tumour of the head and neck. Dentomaxillofac Radiol. 34(5):274-278, 2005.
◆Sato T, Kawabata Y, Kobayashi Y, Suenaga S, Indo H, Kawano K, Iwashita Y, Morita Y, Majima HJ: Scintigraphy for interpretation of malignant tumours of the head and neck: comparison of technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI) and thallium- 201-chloride (Tl-201). Dentomaxillofac Radiol. 34(5):268-273, 2005.
◆Yen HC, Tang YC, Chen FY, Chen SW, Majima HJ: Enhancement of Cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. Ann N Y Acad Sci. 1042:516-522, 2005.
◆Kawatoko S, Sato T, Kawabata Y, Suenaga K, Suenaga S, Morita Y, Indo H, Kawano K, Iwashita Y, Majima H, Sugihara K, Semba I: A trial for histopathological subclassification of papillary cystadenoma lymphomatosum by 99Tcm-pertechnetate in a patient with multiple bilateral lesions of the parotid glands. Dentomaxillofac Radiol. 34(4):218-221, 2005.
◆Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, Nitta T, Sugihara K, Majima H: Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck. Dentomaxillofac Radiol. 34(4):212-217, 2005.
◆Yen HC, Chang HM, Majima HJ, Chen FY, Li SH. : Levels of reactive oxygen species and primary antioxidant enzymes in WI38 versus transformed WI38 cells following bleomcyin treatment. Free Radic Biol Med. 38(7):950-959, 2005.
◆Kakinuma S, Nishimura M, Kubo A, Nagai J, Amasaki Y, Majima HJ, Sado T, Shimada Y: Frequent retention of heterozygosity for point mutations in p53 and Ikaros in N-ethyl-N- nitrosourea-induced mouse thymic lymphomas, Mutation Research, 572, 132?141, 2005.
◆Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimo-Onoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T: Increased expression of humanin peptide in diffuse type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann Rheum Dis. 2004 (Nov 26th on line).
◆Hiroko Kariyazono, Kazuo Nakamura, Junko Arima, Osamu Ayukawa, Shunji Onimaru, Hiroshi Masuda, Yoshifumi Iguro, Hideyuki J Majima, Ryuzo Sakata and Katsushi Yamada: Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood. Blood Coagulation & Fibrinolysis 15(2), 157-167, 2004 .
◆Futoshi Hirai, Shigeatsu Motoori, Shizuko Kakinuma, Kazuo Tomita, Hiroko P. Indo, Hirotoshi Kato, Taketo Yamaguchi, Hsiu-Chuan Yen, Daret K. St.Clair, Tetsuo Nagano, Toshihiko Ozawa, Hiromitsu Saisho and Hideyuki J. Majima: Mitochondrial Signal Lacking Manganese Superoxide Dismutase Failed to Prevent Cell Death by Reoxygenation following Hypoxia in a Human Pancreatic Cancer Cell Line, KP4. Antioxidant & Redox Signaling, 6(3), 523-535, 2004 .
◆Shizuko Kakinuma,Ayumi Kubo,Yoshiko Amasaki,Kumie Nojima,Manami Monobe,Hideyuki Majima,Tatsuhiko Imaoka,Mayumi Nishimura,Yoshiya Shimada: Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas, Biological Siences in Space, 17(3), 187, 2003.
◆Hsiu-Chuan Yen, Chung-Yi Nien, Hideyuki J. Majima, Chia-Pai Lee, Sz-Yun Chen, and Jeng-Shu Wei: Increase of Lipid Peroxidation by Cisplatin in WI38 but not in SV40-transformed WI38 cells.  J. Biochem. Mol. Toxicol. 17(1): 39-46, 2003.
◆Ken-ichi Setsukinai, Yasuteru Urano, Katsuko Kakinuma, Hideyuki J. Majima, and Tetsuo Nagano: Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J. Biol. Chem. 278(5): 3170-3175, 2003.
◆Sachiko Koike, Koichi Ando, Chisa Oohira, Takeshi Fukawa, Ryonfa Lee, Nobuhiko Takai, Manami Monobe, Yoshiya Furusawa, Mizuho Aoki, Shigeru Yamada, Wakako Shimizu, Kumie Nojima and Hideyuki Majima: Relative biological effectiveness of 290 MeV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma. J. Radiat. Res. (Tokyo), 43(3): 247-55, 2002.
Hideyuki J. Majima, Takako Nakanishi-Ueda, Toshihiko Ozawa: 4-hydroxy-2-nonenal (4-HNE) staining by anti-HNE antibody. Methods Mol. Biol. 196:31-34, 2002.
◆Shigeatsu Motoori, Hideyuki J. Majima, Masaaki Ebara, Hirotoshi Kato, Futoshi Hirai, Shizuko Kakinuma, Chizuru Yamaguchi, Toshihiko Ozawa, Tetsuo Nagano, Hirohiko Tsujii and Hiromitsu Saisho: Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line, HLE. Cancer Res. 61:5382-5388, 2001.
◆Yunfeng Zhao, Yi Xue, Terry D. Oberley, Kelley K. Kiningham, Shu-mei Lin, Hsiu-Chuan Yen,, Hideyuki Majima, Judy Hines and Daret St. Clair.: Overexpression of MnSOD suppresses tumor formation by modulation of AP-1 signaling in a multistage skin carcinogenesis model. Cancer Res. 61: 6082-6088, 2001.
◆Yong Xu, Anuradha Krishnan, X. Steven Wan, Hideyuki Majima, Che-Chung Yeh, Gabriele Ludewig, Edward J. Kasarskis, and Daret K. St Clair: Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells, Oncogene, 18:93-102, 1999.
Hideyuki J. Majima, Masao Suzuki, Koichi Ando, Koh-ichi Sakata, Norio Suzuki, Shigefumi Okada, Shozo Suzuki, Tadaaki Miyamoto, Kazunobu Fujitaka, Hiroshi Fuji, Shigeru Yamada, Hirohiko Tsujii and Muneyasu Urano: Theoretical strategy: How to make treatment planning for heavy ion-beam therapy ?, Jpn. J. Med. Phys. 19:37-47, 1999.
◆Yong Xu, Kelley K. Kiningham, Madhav N. Devalaraja, Che-Chung Yeh, Hideyuki Majima, Edward J. Kasarskis and Daret K. St. Clair :An intronic NF-_B element is essentia for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-_ and interleukin-1_, DNA and Cell Biology, 18:709-722, 1999.
Hideyuki J. Majima, Terry D. Oberley, Katsutoshi Furukawa, Mark P. Mattson, Hsiu-Chuan Yen, Luke I. Szweda and Daret K. St.Clair: Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J. Biol. Chem., 273:8217-8224, 1998.
◆Soichiro Ando, Kumie Nojima, Hideyuki Majima, Hiroshi Ishihara, Masao Suzuki, Yoshiya Furusawa, Hiroshi Yamaguchi, Sachiko Koike, Koichi Ando, Masatake Yamauchi, and Takayuki Kuriyama: Evidence for mRNA expression of Vascular Endothelial Growth Factor by X-ray irradiation in a Lung Squamous Carcinoma Cell Line. Cancer Letter,132:75-80, 1998.

<主な著作>

◆Eds.:K.Fujitaka, H.Majima, K.Ando, H.Yasuda, M.Suzuki. Kodansha: Risk evaluation of cosmic_ray exposure in long-term manned space mission Scientific ltd. Tokyo,1999.
馬嶋秀行、小澤俊彦:細胞内における抗酸化酵素のGreen Chemistry における役割、Foods &Food Ingredients Journal of Japan 186:11-14, 2000.
◆ Eds.:H.J. Majima, K.Fujitaka: Exporing future research strategies in space radiation sciences. Iryokagakusha, Co. Ltd, Tokyo, 2000.
馬嶋秀行、山口千鶴、柿沼志津子、本居成淳、平井 太、山口洋子、富田和男、小澤俊彦:放射線障害に対する細胞内ミトコンドリアの役割、新ミトコンドリ ア学、p283-p288、共立出版、東京、 2001.
Hideyuki J. Majima, Takako Nakanishi-Ueda, and Toshihiko Ozawa: 4-Hydroxy-2-Nonenal (4-HNE) Staining by Anti-HNE Antibody. In Oxidants and Antioxidants. Ultrastructure andmolecular Biology Protocols. Ed. D. Armstrong. Methods in Molecular Biology. Vol 196, Humana Press, New Jersey, pp.31-34, 2002.
Majima HJ, Indo HP, Tomita K, Suenaga S, Motoori S, Kato H, Yen H-C and Ozawa T. Intracellular oxidative stress caused by ionizing radiation, In Oxidative Stress, Disease and Cancer, ed. Singh K., Imperial College Press, London, UK, pp 61-83, 2006.
馬嶋秀行:酸化ストレス関連疾患におけるミトコンドリアの役割、別冊 医学のあゆみ 酸化ストレスVer.2フリーラジカル医学生物学の最前線、吉川敏一編、医歯藥出版株式会社、東京、pp248-250, 2006.
◆犬童寛子、富田和男、松井裕史、小澤俊彦、馬嶋秀行: 放射線感受性におけるミトコンドリアの役割、放射線生物研究42(4), p416-427, 2007.
馬嶋秀行、犬童寛子、富田和男、松井裕史、小澤俊彦:ミトコンドリア・アポトーシスと酸化ストレス、酸化ストレスの医学、吉川敏一監修、内藤裕二、豊國伸哉編集、診断と治療社、東京、pp81-87、2008.
◆犬童寛子、富田和男、馬嶋秀行:MnSODによるラット胃癌細胞RGK1における酸化ストレス誘導蛋白発現抑制調節、G.I.Research, 16(4):90-91, 2008.
馬嶋秀行:国際宇宙ステーションにおけるヒト神経細胞宇宙実験「Neuro Rad」―ヒト長期宇宙滞在 神経細胞に何がおこるか?―(ISS Space Experiment using Human Neuroblastoma Cells "Neuro Rad"-Long-term manned space mission-What occur in human neuron-like cells?-)、鹿児島大学歯学部紀要、30巻:23-31, 2010.
馬嶋秀行、犬童寛子:国際宇宙ステーション「きぼう」におけるヒト神経細胞宇宙実験「Neuro Rad」、 鹿児島県歯科医師会報, Vol.91, No.670, pp.8-10, 2010.
馬嶋秀行、鮫島義宏廣:宇宙焼酎醸造にかけるロマン、医学部医師会報 第31号、 52-54, 2011.
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( I'm )      Prof. Hideyuki J. MAJIMA. D.D.S. Ph. D 
( Office ) Kagoshima Univ. Grad. School of Medical and Dental Science. Dept. of Maxillofacial Radiology.
( Address) Sakuragaoka 8-35-1, Kagoshima city, Kagoshima Japan.
( E-mail )  hmajima@dent.kagoshima-u.ac.jp